Zocor (Simvastatin) is a prescribed medication of the class known as HMG CoA Reductase inhibitors (Statins). It is used for hyperlipidemia (high cholesterol). It is considered highly unsafe in pregnancy and nursing. The usual starting dose is 20-40mg once daily. Zocor is broken down in the body by the cytochrome P450 enzyme; therefore those drug which inhibit cytochrome P450 (certain macrolides, antifungals, HIV protease inhibitors and grapefruit) prolong the presence of Zocor in the blood.
Doses higher than 10mg per day are not recommended when taken with gemfibrozil (lopid) or cyclosporine; do not exceed 20mg per day when used with amiodarone or verapamil. Use with caution with fibrates, like gemfibrozil, or with doses of niacin greater than 1 gm per day as this may cause myopathy (muscle disease). Do not use in patients with active liver disease or with unexplained persistently elevated liver enzymes.
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