Isotrex (Isotretinoin) is a prescribed medication used in the treatment of severe acne. It is absolutely contraindicated (prohibited) in women who are pregnant or might become pregnant. If used in a woman of childbearing age, the patient must have severe, disfiguring acne, must be reliable, must comply with mandatory contraceptive measures, must receive written and oral instructions about the hazards of taking this medicine during pregnancy, and must have 2 negative pregnancy tests prior to beginning therapy. The patient must use 2 effective forms of contraception unless absolute abstinence or hysterectomy, said contraceptive measure to begin 1 month prior to therapy and continue until 1 month after therapy has been stopped. The usual starting dose in 0.5-1mg per kilogram of weight per day. This medication can only be prescribed by healthcare professionals who have undergone specific training. This medication can cause multiple different adverse reactions including, suicidal ideation, depression, aggression or violent behavior, corneal opacities, decreased night vision, inflammatory bowel disease, and pseudotumor cerebri. Avoid using with tetracycline, minocycline, and vitamin A.

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