Glucovance (Glyburide & Metformin) is a prescription diabetes medication. It is considered safe in pregnancy but not in nursing. The usual starting dose is 1.25/250mg once or twice daily with meals. It should not be given in renal disease or dysfunction, or in CHF requiring drug treatment, or in metabolic acidosis or diabetic ketoacidosis. Iodinated contrast should not be given during or within 48 hours after use. This drug has multiple interactions with other drugs, and multiple adverse side effects. A review of the literature is recommended prior to initiation of therapy.
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