Cialis (tadalafil) is a prescribed medicine for erectile dysfunction. It is in the class of drugs known as phosphodiesterase inhibitors. It is taken once daily before sexual activity, usually with a starting dose of 10mg, adjusting thereafter. In men with kidney or liver problems the starting dose is lower. Its use with alpha-blocker drugs and nitrates (like nitroglycerin) can bottom-out your blood pressure and concomitant use with these medicines is therefore prohibited. Cialis is broken down in the body by an enzyme known as CYP3A4. Some drugs, including certain antivirals, antifungals, erythromycin, tagamet and even grapefruit, inhibit CYP3A4 and therefore prolong Cialis' presence in the blood stream requiring a lower dose of Cialis if used concomitantly. The most concerning side effect is priapism, a condition in which the penis remains stiff for several hours. You should see a physician immediately if your erection lasts longer than 2 hours.
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